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What is Parkinson's disease?

Parkinson’s disease is the second most common age-related neurodegenerative condition (after Alzheimer’s disease). It is considered a movement disorder, causing “motor symptoms” such as tremor, slowness of movement, stiffness and balance difficulties. Most patients will have “non-motor” symptoms such as loss of smell, constipation and mood disturbance prior to the onset of their motor symptoms. Symptoms are mainly due to loss of neurons (nerve cells) in the brain which produce dopamine (a chemical messenger), specifically within an area called the substantia nigra.

Parkinson’s disease affects more than 1% of those aged over 60. Advancing age is the biggest risk factor for Parkinson’s disease, however a combination of genetic and environmental factors are also thought to contribute to its development. Young onset Parkinson’s refers to those with symptoms prior to age 50; the majority of these cases are associated with an underlying genetic abnormality.

Causes

Causes of Parkinson's disease

The exact cause of Parkinson’s disease is not fully understood. However, researchers believe that a combination of genetic and environmental factors contribute to its development. The incidence of Parkinson’s disease tends to increase with age.

Symptoms

Symptoms of Parkinson's disease

The symptoms of Parkinson’s disease can vary from person to person and usually develop gradually over time.

Non-motor symptoms (usually precede development of motor symptoms by a number of years):

  • Loss of smell
  • Constipation
  • Urinary retention
  • Postural hypotension (dizziness on standing)
  • Sleep disturbances (restless legs syndrome, REM sleep behaviour disorder)
  • Anxiety and depression
  • Psychosis
  • Cognitive changes (mild cognitive impairment / dementia)
parkinsons disease treatment

As people age the risk of Parkinson’s disease increases.

Motor symptoms:

  • Bradykinesia (slowed movements, slow/soft speech, reduced size of handwriting)
  • Tremor (typically starting in the hands or fingers)
  • Muscle rigidity or stiffness in the limbs and trunk
  • Postural instability (balance problems)
  • Freezing of movements (inability to make voluntary movements)
  • Dysphagia (difficulty swallowing)
Diagnosis

Diagnosis of Parkinson's disease

Diagnosing Parkinson’s disease can be challenging, as there is no single test to definitively confirm the presence of the condition. Parkinson’s disease is considered a clinical diagnosis, which is based on a detailed medical history, a thorough neurological examination, and observation of the characteristic symptoms.

Additional investigations , such as CT, MRI or PET imaging, and genetic testing may be used to rule out other conditions that can mimic Parkinson’s disease.

Treatment

Treatment plan for Parkinson's disease

There is currently no cure for Parkinson’s disease, however multiple treatment strategies exist to assist in the management of symptoms. The treatment approach is tailored to each individual and will vary depending on their specific needs and disease progression. A combination of non-pharmacologic therapy (speech therapy, physiotherapy and occupational therapy) and pharmacologic therapy (medication / advanced treatments) is required in most cases.

Non-pharmacologic treatment:

  • Lifestyle Modifications: A healthy lifestyle that includes regular exercise, a balanced diet, and stress management techniques can help manage symptoms and improve overall well-being.
  • Physiotherapy: Exercises and physical therapy programs can help improve mobility, balance, and muscle strength, enabling individuals with Parkinson’s disease to maintain their independence and manage symptoms effectively.
  • Speech Therapy: Speech and swallowing difficulties are common in Parkinson’s disease. Speech therapy can help improve communication skills, articulation, and swallowing function.
  • Occupational Therapy: Occupational therapy focuses on enhancing daily living skills, adapting to the environment, and using assistive devices to promote independence and improve quality of life.

Pharmacologic / advanced therapy:

  • Medications: Certain medications can help increase dopamine levels or mimic its effects on the brain, providing relief from motor symptoms. These include levodopa, dopamine agonists, MAO-B inhibitors, and COMT inhibitors. In select patients, additional medications may be required to manage non-motor symptoms such as postural hypotension (fludrocortisone, midodrine), anxiety and depression (antidepressants) or psychosis (antipsychotics)
  • Deep Brain Stimulation (DBS): This surgical procedure involves implanting a device that delivers electrical impulses to specific areas of the brain. DBS can effectively reduce symptoms such as tremors, rigidity, and bradykinesia in carefully selected patients.
Conclusion

Conclusion

Parkinson’s disease is a complex neurodegenerative condition that can significantly impact a person’s quality of life. While there is currently no cure for Parkinson’s disease, there are treatment options available to manage its symptoms and improve overall well-being. Treatments such as physiotherapy, speech pathology and occupational therapy, alongside medications, can help individuals with Parkinson’s disease maintain their independence. Early diagnosis and treatment can result in improved symptom management and a higher quality of life.

Why Choose Us

Choose CURA Medical Specialists for your Parkinson's disease treatment

Our experienced team at CURA Medical Specialists specialise in providing personalised, expert care for those with Neurologic conditions. Contact us today to schedule your consultation.

Meet our friendly and professional team

Dr Hugh Stephen Winters

Dr. Hugh Stephen Winters

MBChB (Auckland) FRACP (Neurology) CCINR (Neurology)

Dr Hugh Stephen Winters is a skilled interventional neurologist with extensive expertise in utilising modern techniques for the diagnosis and treatment of conditions such as stroke, idiopathic intracranial hypertension, and aneurysms.

Dr. Timothy Ang

MBBS, FRACP (Neurology), Head of Committee for CCINR

Dr Timothy Ang is a highly skilled interventional neurologist who uses cutting-edge medical imaging to diagnose and treat neurovascular and neurological diseases, including stroke, intracranial hypertension, headache, migraine and aneurysms.

Dr Timothy Ang
Dr Kartik Bhatia

Dr. Kartik Bhatia

MBBS, BMedSci (Hons), MS, PhD, FRANZCR, CCINR

Dr Kartik Bhatia is an interventional neuroradiologist who treats both children and adults.

Dr. Christopher Blair​

BSc (Hons I), MBBS (Hons I), DPhil (York), FRACP

Dr Christopher Blair​ neurology advanced trainee from the Royal Prince Alfred Hospital and Liverpool Hospitals Chris has gained rich experience in the treatment of all types of neurological disorders.

Dr. Christopher Blair
FAQ

FAQs

For more information please read our most frequently asked questions:

The three main treatment strategies for Parkinson’s disease are:
  • Allied healthcare – physiotherapy, speech pathology and occupational therapy
  • Medications – levodopa, dopamine agonists, MAO-B inhibitors, and COMT inhibitors. In some patients, additional medications may be required to manage non-motor symptoms such as postural hypotension (fludrocortisone, midodrine), anxiety and depression (antidepressants) or psychosis (antipsychotics)
  • Deep brain stimulation – in select patients (may include those with significant tremor or young onset Parkinson’s disease)

The exact cause of Parkinson’s disease is not known, but it is believed to occur due to a combination of genetic and environmental factors.

Parkinson’s disease is characterised by the following four main signs:

  • Bradykinesia (slowed movements, slow/soft speech, reduced size of handwriting)
  • Tremor (typically starting in the hands or fingers)
  • Muscle rigidity or stiffness in the limbs and trunk
  • Postural instability (balance problems)

Parkinson’s disease is a progressive condition, meaning that symptoms will gradually worsen with time. The speed and extent to which symptoms worsen varies substantially between individuals. With increasing time from symptom onset, “non-motor” symptoms, such as mood disturbance or cognitive difficulties may become more prominent than “motor” symptoms, and can substantially impact quality of life.

Progressive supranuclear palsy (PSP) is considered a “Parkinson’s plus syndrome,” meaning that there is some overlap in symptoms between Parkinson’s disease and PSP. However each condition has distinct clinical characteristics and requires a different treatment approach. Consulting with a medical professional is essential for an accurate diagnosis and appropriate management.

PLEASE NOTE: This information is not intended to be used for diagnosis or treatment. It is aimed at presenting a perspective only and is not a substitute for a prescription or clinical assessment. Anyone experiencing a medical condition should consult their doctor.
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